羊膜腔内注射1,2-³H-皮质醇后的动力学
The kinetics of 1,2-3H-cortisol after intra-amniotic administration.
作者信息
Dostál M, Musil J
出版信息
Folia Biol (Praha). 1977;23(4):283-90.
Foetuses of random-bred H mice (Velax) received on day 13 of foetal development 1,2-3H-cortisol by the intra-amniotic administration, and 10, 20, 30, 60 and 120 min. after drug injection the radioactivity in the amniotic fluid, foetuses and placentae was determined by methanol extraction. The mean value of total radioactivity in the foetuses and placentae attained 2.2% and 2.7%, respectively, of the injected dose during the first 10 min. and did no longer change substantially. Total radioactivity in the amniotic fluid, after an initial acute fall, corresponded to 16.4% of injected dose from 20 min. to 2 hours after drug administration.
在胎儿发育第13天，通过羊膜腔内给药，将1,2 - ³H - 皮质醇给予随机繁殖的H品系小鼠（Velax）胎儿。在注射药物后10、20、30、60和120分钟，通过甲醇提取法测定羊水、胎儿和胎盘的放射性。在最初的10分钟内，胎儿和胎盘的总放射性平均值分别达到注射剂量的2.2%和2.7%，之后基本不再变化。给药后，羊水总放射性在最初急剧下降后，在20分钟至2小时内相当于注射剂量的16.4%。
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