Lev-Ran A, Goldman J A
Diabetes. 1977 Oct;26(10):926-30.
In eight brittle diabetics the insulin requirement increased during successful pregnancies from 35 to 64 U./day (in 29 stable severe diabetics from 53 to 78 U./day). The within-day glycemic excursions were calculated as the mean of the three differences between four time points: fasting, one hour after breakfast, two hours after breakfast, and two hours after lunch. This parameter was constant throughout the pregnancy in nondiabetics (34-46 mg./100 ml.) and stable severe diabetics (55-72 mg./100 ml.). In brittle diabetics it dropped from 147 mg./100 ml. before the pregnancy and 153 mg./ 100 ml. at eight weeks to 85 mg./100 ml. at 36 weeks. The between-day variability was calculated as the mean glycemic difference between two successive days at the four points of time noted above. It was very low in nondiabetics (49-53 mg./100 ml.). In brittle diabetics it decreased from 127 mg./100 ml. before pregnancy and 120 mg./100 ml. at eight weeks to 46-55 mg./100 ml. at 24-36 weeks. This shows that brittleness substantially decreased in the second half of pregnancy.
在8例脆性糖尿病患者中，成功妊娠期间胰岛素需求量从每日35单位增加至64单位（29例病情稳定的重度糖尿病患者从每日53单位增加至78单位）。日内血糖波动幅度通过计算四个时间点（空腹、早餐后1小时、早餐后2小时和午餐后2小时）之间三个差值的平均值得出。在非糖尿病患者（34 - 46毫克/100毫升）和病情稳定的重度糖尿病患者（55 - 72毫克/100毫升）整个孕期中，该参数保持恒定。在脆性糖尿病患者中，其在妊娠前为147毫克/100毫升，妊娠8周时为153毫克/100毫升，至妊娠36周时降至85毫克/100毫升。日间变异性通过计算上述四个时间点连续两天之间的平均血糖差值得出。在非糖尿病患者中该值非常低（49 - 53毫克/100毫升）。在脆性糖尿病患者中，其在妊娠前为127毫克/100毫升，妊娠8周时为120毫克/100毫升，至妊娠24 - 36周时降至46 - 55毫克/100毫升。这表明在妊娠后半期脆性显著降低。
