Holst J J, Madsen O G, Knop J, Schmidt A
Diabetologia. 1977 Sep;13(5):487-90. doi: 10.1007/BF01234501.
The effect of peripheral and intraportal infusions on 0.86 pmol/kg-min-1 of glucagon on plasma glucose, plasma insulin, and glucose tolerance was examined in four normal subjects. Peripheral glucagon concentrations increased by 60--90 pmol/1 during intraportal and 70--180 pmol/1 during peripheral infusions. The infusions caused increases in plasma glucose levels of approximately 1 mmol/1, and in plasma insulin levels of 75--100%, regardless of route of administration. Intravenous glucose tolerance tests carried out during the glucagon infusions showed that glucose tolerance remained within the normal range and was uninfluenced by the route of administration.
在四名正常受试者中，研究了外周和门静脉内输注0.86皮摩尔/千克·分钟⁻¹胰高血糖素对血糖、血浆胰岛素及葡萄糖耐量的影响。门静脉内输注时外周胰高血糖素浓度升高60 - 90皮摩尔/升，外周输注时升高70 - 180皮摩尔/升。无论给药途径如何，输注均使血浆葡萄糖水平升高约1毫摩尔/升，血浆胰岛素水平升高75% - 100%。在胰高血糖素输注期间进行的静脉葡萄糖耐量试验表明，葡萄糖耐量仍在正常范围内，且不受给药途径的影响。
