重度子痫前期患者的人类白细胞抗原

HLA antigens in patients with severe preeclampsia.

作者信息

Takakuwa K, Arakawa M, Tamura M, Hataya I, Higashino M, Yasuda M, Tanaka K

机构信息

Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.

出版信息

J Perinat Med. 1997;25(1):79-83. doi: 10.1515/jpme.1997.25.1.79.

DOI:10.1515/jpme.1997.25.1.79

PMID:9085207

Abstract

The distribution of human leucocyte antigens (HLA) was analyzed in 35 patients with severe preeclampsia and compared with that in the general population in the Niigata district of Japan. The frequency of patients with HLA CW7 was significantly higher than that of the general population of this area (p < 0.05, Chi-square test). The frequency of those with HLA-DR6 (DR6, DR13 and DR14) was also significantly greater compared with the general population (P < 0.05, Chi-square test), while that of those with DR4 was significantly lower (P < 0.05, Chi-square test). The compatibility of HLA antigens in spouses was also analyzed in 20 patient couples and 26 normal fertile couples, and there was no significant difference. Thus it is suggested that HLA antigen systems might be involved in the genesis of preeclampsia.

摘要

对35例重度子痫前期患者的人类白细胞抗原（HLA）分布进行了分析，并与日本新潟地区的普通人群进行了比较。HLA CW7患者的频率显著高于该地区普通人群（p<0.05，卡方检验）。与普通人群相比，HLA-DR6（DR6、DR13和DR14）患者的频率也显著更高（P<0.05，卡方检验），而DR4患者的频率则显著更低（P<0.05，卡方检验）。还对20对患者夫妇和26对正常生育夫妇的HLA抗原相容性进行了分析，未发现显著差异。因此，提示HLA抗原系统可能参与子痫前期的发生。