Wasley M A, McNagny S E, Phillips V L, Ahluwalia J S
Emory University School of Medicine, Atlanta, Georgia 30303, USA.
Prev Med. 1997 Mar-Apr;26(2):264-70. doi: 10.1006/pmed.1996.0127.
Smoking is the single most preventable cause of premature mortality in the United States. In 13 double-blind, controlled trials, the nicotine transdermal patch has been demonstrated to be an effective aid to quitting smoking, even after 6 months of follow-up. Because physicians and payers may consider the cost of the patch to be prohibitive, we examine the cost-effectiveness of the nicotine patch as an adjunct to brief physician counseling during routine office visits.
We estimate the effectiveness of both patch use with brief counseling and counseling alone from meta-analysis of clinical trials. Benefits are measured in terms of years of life gained by those who quit, discounted at 5%. Costs include physician time and patch prescriptions. The incremental cost-effectiveness is quantified as cost per additional year of life saved when patch plus counseling is compared with brief physician counseling alone.
Depending on age, the average costs per year of life saved range from $965 to $1,585 for men and from $1,634 to $2,360 for women. Incremental costs per year of life saved range from $1,796 to $2,949 for men and from $3,040 to $4,391 for women.
The nicotine patch is cost-effective and less costly per year of life saved than other widely accepted medical practices. Physicians and third-party payers should recommend the nicotine patch to patients who wish to stop smoking.
在美国,吸烟是过早死亡的唯一最可预防的原因。在13项双盲对照试验中,尼古丁透皮贴剂已被证明是一种有效的戒烟辅助手段,即使在随访6个月后也是如此。由于医生和支付方可能认为该贴剂成本过高,我们研究了尼古丁贴剂作为常规门诊期间简短医生咨询辅助手段的成本效益。
我们通过对临床试验的荟萃分析来估计使用贴剂并进行简短咨询以及仅进行咨询的效果。益处通过戒烟者获得的生命年数来衡量,贴现率为5%。成本包括医生的时间和贴剂处方。当将贴剂加咨询与仅进行简短医生咨询进行比较时,增量成本效益量化为每多挽救一年生命的成本。
根据年龄不同,男性每挽救一年生命的平均成本在965美元至1585美元之间,女性在1634美元至2360美元之间。男性每挽救一年生命的增量成本在1796美元至2949美元之间,女性在3040美元至4391美元之间。
尼古丁贴剂具有成本效益,而且与其他广泛接受的医疗措施相比,每挽救一年生命的成本更低。医生和第三方支付方应向希望戒烟的患者推荐尼古丁贴剂。