前列腺素E2和F2α对棉球肉芽肿磷脂代谢的影响（作者译）

[Effects of prostaglandin E2 and F2alpha on the phospholipid metabolism in cotton pellet granuloma (author's transl)].

作者信息

Yamada K, Aizawa Y

出版信息

Nihon Yakurigaku Zasshi. 1977 May;73(4):497-500. doi: 10.1254/fpj.73.497.

DOI:10.1254/fpj.73.497

Abstract

Effects of prostaglandin (PG)s on phospholipid metabolism in cotton pellet granuloma were studied. Fifty ng of PGE2 or PGF2alpha was injected twice a day for 3 days into cotton pellet which was implanted into the interscapular region of rats. Phospholipid content in granuloma tissue treated with PGE2 was about 3 times that of control. The incorporation of 32P-orthophosphate into phosphatidylcholine in granuloma treated with PGE2 was about 6 times that of control. The incorporation of 32P-orthophosphate into phosphatidylethanolamine was increased by PGF2alpha but not by PGE2. These results suggest that PGE2 and PGF2alpha have a different site of action in the proliferative inflammatory process.

摘要

研究了前列腺素（PG）对棉球肉芽肿中磷脂代谢的影响。将50纳克前列腺素E2或前列腺素F2α每天注射两次，连续注射3天到植入大鼠肩胛间区域的棉球中。用前列腺素E2处理的肉芽肿组织中的磷脂含量约为对照组的3倍。用前列腺素E2处理的肉芽肿中32P-正磷酸盐掺入磷脂酰胆碱的量约为对照组的6倍。32P-正磷酸盐掺入磷脂酰乙醇胺的量因前列腺素F2α而增加，但不因前列腺素E2而增加。这些结果表明，前列腺素E2和前列腺素F2α在增殖性炎症过程中具有不同的作用位点。