消除抑制细胞对豚鼠二硝基氯苯接触敏感性发展的影响。
Effect of the elimination of suppressor cells on the development of DNCB contact sensitivity in guinea-pig.
作者信息
Polak L, Rinck C
出版信息
Immunology. 1977 Sep;33(3):305-11.
Abstract
The effect of suppressor cells on the formation of effector cells was studied by comparing the development of DNCB contact sensitivity in cyclophosphamide-treated (suppressor cells eliminated) and non-treated (suppressor cells present) guinea-pigs. From experiments in four different models of generation of effector cells the following conclusions are drawn: (1) impulses activating the formation of effector cells also activate suppressor cells; (2) under conditions of conventional immunization, suppressor cells are activated later than effector cells; (3) elimination of suppressor cells results in an increase in the intensity and duration of specific skin reactions.
摘要
通过比较环磷酰胺处理（抑制细胞被消除）和未处理（存在抑制细胞）的豚鼠中DNCB接触敏感性的发展，研究了抑制细胞对效应细胞形成的影响。从四种不同效应细胞生成模型的实验中得出以下结论：（1）激活效应细胞形成的冲动也会激活抑制细胞；（2）在传统免疫条件下，抑制细胞比效应细胞激活得晚；（3）消除抑制细胞会导致特异性皮肤反应的强度和持续时间增加。
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本文引用的文献
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Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene.关于抗原对已致敏于二硝基氯苯的豚鼠诱导免疫耐受的研究。
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