特发性膜性肾病与HLA - DRW3之间存在强关联。
Strong association between idiopathic membranous nephropathy and HLA-DRW3.
作者信息
Klouda P T, Manos J, Acheson E J, Dyer P A, Goldby F S, Harris R, Lawler W, Mallick N P, Williams G
出版信息
Lancet. 1979 Oct 13;2(8146):770-1. doi: 10.1016/s0140-6736(79)92118-4.
PMID:90863
Abstract
HLA A, B, and DR antigens were determined in a homogeneous group of patients with idiopathic membranous nephropathy. The frequency of HLA-DRW3 was significantly higher in the patients than in a control population. The frequencies of HLA B8 and B18, which are in linkage disequilibrium with DRW3, were also increased.
摘要
在一组患有特发性膜性肾病的同质患者中测定了 HLA A、B 和 DR 抗原。患者中 HLA-DRW3 的频率显著高于对照组人群。与 DRW3 处于连锁不平衡状态的 HLA B8 和 B18 的频率也有所增加。
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