Zacur H, Kaufman S C, Smith B, Westhoff C, Helbig D, Lee Y J, Gentile G
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gynecol Endocrinol. 1997 Feb;11(1):29-33. doi: 10.3109/09513599709152314.
Correlation between urinary pregnanediol and serum progesterone measurements and the influence of age, race, smoking and urinary creatinine adjustment was determined during the luteal phase of the menstrual cycle in 175 volunteers. A decline in serum progesterone was observed with increasing age. Mean baseline urinary creatinine declined with increasing age in non-smokers and was not affected by race or baseline weight. An excellent correlation between urinary pregnanediol glucuronide and serum progesterone levels existed except when urinary pregnanediol concentrations were adjusted using creatinine measurements in older individuals. Adjustment of urinary pregnanediol glucuronide concentration using creatinine measurement is therefore discouraged.
在175名志愿者月经周期的黄体期，测定了尿孕二醇和血清孕酮测量值之间的相关性，以及年龄、种族、吸烟和尿肌酐校正的影响。观察到血清孕酮随年龄增长而下降。非吸烟者的平均基线尿肌酐随年龄增长而下降，且不受种族或基线体重的影响。除了在老年个体中使用肌酐测量值校正尿孕二醇浓度时，尿孕二醇葡萄糖醛酸苷与血清孕酮水平之间存在极好的相关性。因此，不建议使用肌酐测量值校正尿孕二醇葡萄糖醛酸苷浓度。
