Takede Y
Research Institute, International Medical Center of Japan.
Nihon Rinsho. 1997 Mar;55(3):635-40.
In 1997, Konowalchuk and coworkers reported a toxin produced by Escherichia coli that was cytotoxic to Vero cells. This toxin(Vero toxin, VT) was subsequently found to be an important virulence factor of E. coli associated with an outbreak of hemorrhagic colitis due to E. coli O157:H7 which occurred in the state of Oregon and Michigan in US. E. coli O157:H7 was then found to produce VT, which was cross-reactive with Shiga toxin produced by Shigella dysenteriae. VT(Shiga-like toxin Shiga toxin, Shiga toxin family) is the toxin which contributes to the symptoms of hemorrhagic colitis and hemolytic uremic syndrome. This article presents a historical perspective on EHEC and also reviews the structure and function of VT as well as epidemiological aspects of outbreak and sporadic cases of EHEC in American continent and in our county.
1997年，科诺瓦尔丘克及其同事报告了一种由大肠杆菌产生的对Vero细胞具有细胞毒性的毒素。这种毒素（Vero毒素，VT）随后被发现是大肠杆菌的一种重要毒力因子，与美国俄勒冈州和密歇根州发生的由大肠杆菌O157:H7引起的出血性结肠炎疫情有关。随后发现大肠杆菌O157:H7产生的VT与痢疾志贺菌产生的志贺毒素有交叉反应。VT（类志贺毒素、志贺毒素，志贺毒素家族）是导致出血性结肠炎和溶血尿毒综合征症状的毒素。本文介绍了肠出血性大肠杆菌的历史背景，并综述了VT的结构和功能，以及美洲大陆和我国肠出血性大肠杆菌疫情和散发病例的流行病学情况。
