MacDougall J D, Ward G R, Sale D G, Sutton J R
J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):700-3. doi: 10.1152/jappl.1977.43.4.700.
Nine healthy subjects were studied under control conditions and following 5 mo of heavy resistance training and 5 wk of immobilization in elbow casts. Needle biopsies were taken from triceps brachii and analyzed for adenosine triphosphate (ATP), adenosine diphosphate (ADP), creatine (C), creatine phosphate (CP, and glycogen concentrations. Training resulted in an 11% increase in arm circumference and a 28% increase in maximal elbow extension strength. Immobilization resulted in decreases in arm circumference and elbow extension strength of 5% and 35%, respectively. Training also resulted in significant increases in resting concentrations of muscle creatine (by 39%), CP (by 22%), ATP (by 18%), and glycogen (by 66%). Conversely, immobilization significantly reduced CP concentration by 25% and glycogen concentration by 40%. It was concluded that heavy-resistance training results in increases in muscle energy reserves which may be reversed by a period of immobilization-induced disuse.
对9名健康受试者在对照条件下、5个月的重度抗阻训练后以及肘部石膏固定5周后进行了研究。从肱三头肌取针吸活检样本，分析三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、肌酸（C）、磷酸肌酸（CP）和糖原浓度。训练使上臂围增加了11%，最大伸肘力量增加了28%。固定导致上臂围和伸肘力量分别下降了5%和35%。训练还使肌肉静息状态下的肌酸浓度显著增加（增加了39%）、CP浓度（增加了22%）、ATP浓度（增加了18%）和糖原浓度（增加了66%）。相反，固定使CP浓度显著降低了25%，糖原浓度降低了40%。得出的结论是，重度抗阻训练会导致肌肉能量储备增加，而一段固定诱导的废用期可能会使其逆转。
