Johnson E E, Hedley-Whyte J, Hall S V
J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):714-20. doi: 10.1152/jappl.1977.43.4.714.
Sulfobromophthalein sodium (BSP) 25 mg/kg body wt was given as a single iv injection to 32 fasted dogs. Serum samples at 3, 5, 10, 20, 30, 45, 60, 80, and 120 min postinjection were analyzed for total concentration of BSP and from 30 to 120 min for percent conjugated BSP. Four groups were compared: spontaneous ventilation; intermittent positive-pressure ventilation (IPPV) and continuous positive-pressure ventilation (CPPV) (2 groups). During CPPV, one group of dogs was given a continuous infusion of cholecystokinin octapeptide (CCK-8, 1 ng/kg per min). Central venous pressure averaged 11.3 +/- 0.7 (SE) cmH2O in dogs with CPPV + CCK-8 and 11.8 +/- 0.8 (SE) cmH2O in dogs with CPPV alone. At 3, 5, and 10 min postinjection serum BSP levels were similar in all groups. From 30 to 120 min postinjection serum levels of both free and conjugated BSP were higher in dogs ventilated with CPPV alone than in any other group (P less than 0.01). Dogs given CCK-8 during CPPV had serum BSP levels that were statistically similar to dogs breathing spontaneously or ventilated with IPPV. We conclude that CPPV impairs BSP excretion. This effect is counteracted by CCK-8.
将25毫克/千克体重的磺溴酞钠（BSP）以单次静脉注射的方式给予32只禁食的狗。在注射后3、5、10、20、30、45、60、80和120分钟采集血清样本，分析BSP的总浓度，并在30至120分钟分析结合型BSP的百分比。比较了四组：自主通气；间歇正压通气（IPPV）和持续正压通气（CPPV）（两组）。在CPPV期间，一组狗持续输注八肽胆囊收缩素（CCK - 8，每分钟1纳克/千克）。接受CPPV + CCK - 8的狗的中心静脉压平均为11.3±0.7（SE）厘米水柱，仅接受CPPV的狗的中心静脉压平均为11.8±0.8（SE）厘米水柱。在注射后3、5和10分钟时，所有组的血清BSP水平相似。在注射后30至120分钟，仅接受CPPV通气的狗的游离型和结合型BSP血清水平均高于其他任何组（P<0.01）。在CPPV期间接受CCK - 8的狗的血清BSP水平在统计学上与自主呼吸或接受IPPV通气的狗相似。我们得出结论，CPPV会损害BSP的排泄。这种作用可被CCK - 8抵消。
