Nakamura K, Shirai J, Imai K, Hihara H, Tanimura N
Third Research Division, National Institute of Animal Health, Ibaraki, Japan.
Avian Dis. 1997 Jan-Mar;41(1):252-6.
Comb necrosis with leg weakness was seen in 41-day-old female layer breeder chickens. This disease occurred in three flocks at a breeder farm, but not in other flocks of growing chickens and broiler breeder hens at the same farm. The disease started in 35-day-old chicks in three flocks. The morbidity of comb necrosis was 10% and that of leg weakness was 3%. Characteristic gross lesions of affected chickens were swelling and necrosis of the whole comb. Histologically, liquefactive necrosis of epidermal epithelial cells with hyperplasia, vesicle formation in the epidermis, congestion, and hemorrhages with fibrinous thrombi of underlying dermis in the comb were noted. In mature comb lesions, the epidermis showed eosinophilic necrosis (scab formation). In the livers, multiple fibrinous thrombi were present in the sinusoids and there was necrosis of hepatic cells. Staphylococcus aureus and Pasturella spp. were isolated from comb lesions. There were no significant lesions causing leg weakness.
在41日龄的雌性蛋种鸡中发现鸡冠坏死并伴有腿部无力的情况。这种疾病发生在一个种鸡场的三个鸡群中，但同一农场的其他生长鸡群和肉种鸡母鸡群未出现。该病在三个鸡群的35日龄雏鸡中开始出现。鸡冠坏死的发病率为10%，腿部无力的发病率为3%。患病鸡的特征性大体病变为整个鸡冠肿胀和坏死。组织学上，可见表皮上皮细胞液化性坏死伴增生、表皮内水疱形成、充血以及鸡冠下方真皮层有纤维蛋白血栓形成的出血。在成熟的鸡冠病变中，表皮显示嗜酸性坏死（结痂形成）。肝脏中，窦状隙存在多个纤维蛋白血栓，肝细胞坏死。从鸡冠病变中分离出金黄色葡萄球菌和巴氏杆菌属。未发现导致腿部无力的明显病变。
