Sener R N
Department of Radiology, Ege University Hospital, Bornova, TR-35 100 Izmir, Turkey.
Eur Radiol. 1997;7(3):409-11. doi: 10.1007/s003300050176.
Two patients are presented with large cerebral schizencephalic clefts and large temporal arachnoid cysts. Neuropathological studies suggest that arachnoid cysts may either arise due to an aberration in the formation of the subarachnoid space or by its splitting. A recently proposed theory for the formation of schizencephaly is that this condition is an extreme variant of cortical dysplasia, in which the infolding of cortex extends all the way into the lateral ventricle. In light of these data, and based on the imaging findings in our two patients with large cerebral schizencephalic clefts and large temporal arachnoid cysts, we propose that the mechanism which causes schizencephaly (deep cortical infolding) may lead to some kind of a traction effect and splitting of the leptomeninges resulting in the formation of an arachnoid cyst adjacent to the schizencephalic cleft. This appears to be a significant observation because the pathogenesis of arachnoid cysts is still controversial.
本文报告了两名患有大脑裂脑畸形和巨大颞叶蛛网膜囊肿的患者。神经病理学研究表明，蛛网膜囊肿可能是由于蛛网膜下腔形成异常或其分裂所致。最近提出的一种关于脑裂畸形形成的理论是，这种情况是皮质发育异常的一种极端变体，其中皮质折叠一直延伸到侧脑室。根据这些数据，并基于我们两名患有大脑裂脑畸形和巨大颞叶蛛网膜囊肿患者的影像学表现，我们提出导致脑裂畸形（深部皮质折叠）的机制可能会导致某种牵引效应和软脑膜分裂，从而在裂脑畸形裂隙附近形成蛛网膜囊肿。这似乎是一个重要的观察结果，因为蛛网膜囊肿的发病机制仍存在争议。
