Stuart D I, Jones E Y
Nature. 1997 Apr 3;386(6624):437-8. doi: 10.1038/386437a0.
The proteasome is the most complex eukaryotic macromolecular assembly yet seen in fine detail. The structure reveals completely unexpected mechanisms by which the proteasome neatly chops up unwanted proteins for disposal or display to the immune system.
蛋白酶体是迄今为止在高分辨率下所观察到的最为复杂的真核生物大分子组件。该结构揭示了一些完全出人意料的机制,通过这些机制,蛋白酶体能够巧妙地切割不需要的蛋白质以便进行处理或展示给免疫系统。