胃分化腺癌中21号染色体长臂上的常见缺失区域。
Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach.
作者信息
Sakata K, Tamura G, Nishizuka S, Maesawa C, Suzuki Y, Iwaya T, Terashima M, Saito K, Satodate R
机构信息
Department of Pathology, Iwate Medical University School of Medicine, Uchimaru, Morioka, Japan.
出版信息
Genes Chromosomes Cancer. 1997 Apr;18(4):318-21.
During an allelotype analysis of differentiated adenocarcinoma of the stomach, we observed frequent loss of heterozygosity (LOH) on several chromosomes including the long arm of chromosome 21 (21q). Therefore, we analyzed DNA isolated from 45 tumors for LOH at 10 loci on 21q by using polymorphic microsatellite markers. In 20 (44%) of 45 tumors, we detected LOH at single or multiple loci on 21q. Deletion mapping of these 20 tumors revealed two separate commonly deleted regions. Our findings suggest that 21q contains at least two potential tumor suppressor genes which play crucial roles in the development of differentiated adenocarcinoma of the stomach.
在对胃分化腺癌进行等位基因分型分析的过程中，我们观察到包括21号染色体长臂（21q）在内的几条染色体上频繁出现杂合性缺失（LOH）。因此，我们使用多态性微卫星标记，对45个肿瘤中分离出的DNA进行了21q上10个位点的LOH分析。在45个肿瘤中的20个（44%）中，我们在21q的单个或多个位点检测到了LOH。对这20个肿瘤的缺失定位显示出两个独立的常见缺失区域。我们的研究结果表明，21q至少包含两个潜在的肿瘤抑制基因，它们在胃分化腺癌的发生发展中起关键作用。
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