Schwendel A, Richard F, Langreck H, Kaufmann O, Lage H, Winzer K J, Petersen I, Dietel M
Institute of Pathology, Charité, Humboldt University Berlin, Germany.
Br J Cancer. 1998 Sep;78(6):806-11. doi: 10.1038/bjc.1998.583.
Comparative genomic hybridization was applied to map DNA gains and losses in 39 invasive ductal breast carcinomas. Frequent abnormalities included gains on chromosomal regions 1q, 8q, 11q12-13, 16p, 19, 20q and X as well as frequent losses on 1p, 5q, 6q, 9p, 11q, 13q and 16q. Furthermore, frequent losses on 4q (20 cases) and 21q (14 cases) were found for the first time in this tumour type. High copy number amplifications were observed at 8q12-24, 11q11-13 and 20q13-ter. Highly differentiated tumours were associated with gains on 1q and 11q12-13 along with losses on 1p21-22, 4q, 13q, 11q21-ter. Undifferentiated breast carcinomas were characterized by additional DNA imbalances, i.e. deletions of 5q13-23, all of chromosome 9, the centromeric part of chromosome 13 including band 13q14 and the overrepresentation of chromosome X. We speculate that these changes are associated with tumour progression of invasive ductal breast cancer.
采用比较基因组杂交技术对39例浸润性导管癌的DNA增减情况进行图谱分析。常见异常包括染色体区域1q、8q、11q12 - 13、16p、19、20q和X的增益以及1p、5q、6q、9p、11q、13q和16q的缺失。此外，在该肿瘤类型中首次发现4q（20例）和21q（14例）的频繁缺失。在8q12 - 24、11q11 - 13和20q13 - ter观察到高拷贝数扩增。高分化肿瘤与1q和11q12 - 13的增益以及1p21 - 22、4q、13q、11q21 - ter的缺失相关。未分化乳腺癌的特征是存在额外的DNA失衡，即5q13 - 23缺失、整个9号染色体缺失、包括13q14带在内的13号染色体着丝粒部分缺失以及X染色体的过度表达。我们推测这些变化与浸润性导管癌的肿瘤进展有关。
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