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Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.

作者信息

Turchi G, Glatt H R, Seidel A, Puliti A, Sbrana I

机构信息

European Centre for the Validation of Alternative Methods (ECVAM), J.R.C. Environmental Institute, Ispra (Va), Italy.

出版信息

Cell Biol Toxicol. 1997 Mar;13(3):155-65. doi: 10.1023/a:1007302111081.

DOI:10.1023/a:1007302111081
PMID:9088625
Abstract

Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect, However, all four compounds enhanced the frequency of c-mitoses.

摘要

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