Kanbak M, Akpolat N, Ocal T, Doral M N, Ercan M, Erdem K
Department of Anaesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Eur J Anaesthesiol. 1997 Mar;14(2):153-6. doi: 10.1046/j.1365-2346.1997.00081.x.
This present study investigated the effects of intraarticular morphine administration in 1 mg and 5 mg doses on post-operative pain relief and analgesic requirements for patients undergoing arthroscopic procedures. At the end of the operation patients were randomly allocated in a double-blinded fashion into three groups. The control group (Group 1) received normal saline 20 mL intraarticularly. The patients in the second and third groups received intraarticular morphine sulphate 1 and 5 mg in saline 20 mL, respectively. Post-operative pain was assessed on the 1st, 6th and 24th hour by visual analogue scale (VSA). Supplementary analgesic requirement and possible complications were also followed. The intensity of pain and analgesic requirement were reduced more in the morphine 5 mg group than in the control group. It is concluded, that the administration of intraarticular morphine 5 mg provides long-lasting and effective analgesia after knee arthroscopy.
本研究调查了关节腔内注射1毫克和5毫克剂量吗啡对接受关节镜手术患者术后疼痛缓解及镇痛需求的影响。手术结束时，患者以双盲方式随机分为三组。对照组（第1组）关节腔内注射20毫升生理盐水。第二组和第三组患者分别在20毫升生理盐水中加入1毫克和5毫克硫酸吗啡进行关节腔内注射。术后第1、6和24小时通过视觉模拟评分法（VSA）评估疼痛情况。同时记录补充镇痛需求及可能出现的并发症。与对照组相比，5毫克吗啡组的疼痛强度和镇痛需求降低更为明显。得出结论，关节腔内注射5毫克吗啡可为膝关节镜检查术后提供持久有效的镇痛效果。
