Abdallah A N, Boiron J M, Attia Y, Cassaigne A, Reiffers J, Iron A
Département de Biochimie Médicale et Biologie Moléculaire, Université de Bordeaux 2, France.
Hematol Cell Ther. 1997 Feb;39(1):27-32. doi: 10.1007/s00282-997-0027-2.
A cohort of 201 autologous or allogeneic bone marrow transplanted (BMT) patients were included for studying the evolution of circulating tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) by means of repeated plasma determinations. IL-6 levels were high during major transplant-related complications (TRC) or severe graft vs host disease (GVHD). High levels of TNF-alpha seemed to be associated with chronic GVHD but not with acute GVHD or TRC.
纳入了一组201例接受自体或异体骨髓移植（BMT）的患者，通过重复检测血浆来研究循环肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的变化。在主要的移植相关并发症（TRC）或严重的移植物抗宿主病（GVHD）期间，IL-6水平较高。高水平的TNF-α似乎与慢性GVHD相关，但与急性GVHD或TRC无关。
