Wong T Y, Suster S, Mihm M C
Department of Pathology, Brigham and Women's hospital, Boston, MA, USA.
Histopathology. 1997 Mar;30(3):288-93. doi: 10.1046/j.1365-2559.1997.d01-593.x.
We describe three cases of a distinctive cutaneous adnexal neoplasm showing features of eccrine ductal differentiation that were characterized by a prominent squamoid component. The tumours presented as solitary dermal nodules on the head and neck areas and the extremities in elderly patients. Histologically, they were characterized by a prominent squamous proliferation with atypia, keratinous cyst formation and squamous eddies which seemed to merge with areas showing eccrine ductal differentiation, including ductular formations in continuity with eccrine ductal epithelium. Clinical follow-up in one case showed multiple local recurrences over a period of 3 years despite complete surgical excision. Squamoid eccrine ductal carcinoma should be considered in the differential diagnosis of cutaneous adnexal neoplasms showing squamoid and ductal features of differentiation.
我们描述了三例具有独特特征的皮肤附属器肿瘤，其显示出小汗腺导管分化的特征，以显著的鳞状成分表现为特点。这些肿瘤表现为老年患者头颈部和四肢的孤立性真皮结节。组织学上，它们的特征为显著的非典型鳞状增生、角质囊肿形成和鳞状漩涡，这些似乎与显示小汗腺导管分化的区域相融合，包括与小汗腺导管上皮连续的小管形成。尽管进行了完整的手术切除，但一例患者的临床随访显示在3年期间出现多次局部复发。在鉴别诊断具有鳞状和导管分化特征的皮肤附属器肿瘤时，应考虑鳞状小汗腺导管癌。
