Wei J Y, Wang Y H, Go V L, Taché Y
CURE: Digestive Diseases Research Center, Department of Medicine and Brain Research Institute, UCLA School of Medicine 90095, USA.
J Auton Nerv Syst. 1997 Mar 19;63(1-2):12-8. doi: 10.1016/s0165-1838(96)00126-9.
The effect of short-term lower esophageal distension on intragastric pressure (IGP) and the related neural pathways involved were investigated in urethane-anesthetized rats in which enteric nervous system connections were interrupted by ligations of the pylorus and the gastroesophageal junction while keeping the gastric vagus nerve trunks intact. Under these conditions, lower esophageal distension with a bolus of 0.2 to 0.5 ml saline in 0.1 ml step increments, raised the inside esophagus balloon pressure from 1.89 +/- 0.17 to 4.21 +/- 0.13 cm H2O and reduced IGP from -0.42 +/- 0.08 to -0.77 +/- 0.12 cm H2O, respectively. Bilateral cervical vagotomy partly blocked the gastric relaxation induced by 0.5 ml esophageal distension from -0.77 +/- 0.12 to -0.34 +/- 0.02 cm H2O; in contrast, a further bilateral splanchnectomy partly rebounded the effect of 0.5 ml esophageal distension from -0.34 +/- 0.02 to -0.46 +/- 0.05 cm H2O. These results suggest that the enteric nervous system may not play a prominent role in acute esophageal distension induced-gastric relaxation. However, more than 50% of this effect is central nervous system mediated (via the long vago-vagal reflex). The other 40% can be maintained without central and enteric nervous systems involvement, probably via a proposed gastric vagal afferent-esophageal collateral reflex.
在氨基甲酸乙酯麻醉的大鼠中，研究了短期食管下段扩张对胃内压（IGP）的影响以及相关的神经通路。在这些大鼠中，通过结扎幽门和胃食管交界处中断肠神经系统连接，同时保持胃迷走神经干完整。在这些条件下，用0.1 ml步长递增的0.2至0.5 ml生理盐水推注使食管下段扩张，将食管内气囊压力从1.89±0.17 cm H2O提高到4.21±0.13 cm H2O，并将胃内压从-0.42±0.08 cm H2O降低到-0.77±0.12 cm H2O。双侧颈迷走神经切断术部分阻断了由0.5 ml食管扩张引起的胃松弛，从-0.77±0.12 cm H2O降至-0.34±0.02 cm H2O；相反，进一步的双侧内脏神经切除术部分地使0.5 ml食管扩张的作用从-0.34±0.02 cm H2O反弹至-0.46±0.05 cm H2O。这些结果表明，肠神经系统在急性食管扩张诱导的胃松弛中可能不发挥突出作用。然而，这种作用的50%以上是由中枢神经系统介导的（通过长迷走-迷走反射）。另外40%可以在没有中枢和肠神经系统参与的情况下维持，可能是通过一种推测的胃迷走神经传入-食管侧支反射。
