Une T
Microbiol Immunol. 1977;21(7):341-63.
Analysis of the pathogenicity of Yersinia enterocolitica was performed with an experimental model successfully produced in rabbits by intraduodenal inoculation with strains isolated from various sources. Pathogenic strains easily penetrated the epithelial linings of the intestinal mucous membrane into the target reticuloendothelial tissues of the intestine, such as the lamina propria and lymph follicles, where they multiplied within mononuclear cells and produced granuloma. Granuloma, in severe infections, underwent necrobiosis and sometimes progressed to ulceration accompanied by colony formation of the organisms. In mild infections, granulomatous lesions were localized in lymph follicles and never progressed to ulceration. Nonpathogenic strains were rapidly excreted without penetration of epithelial linings. Y. enterocolitica should be within the category of invasion type enteropathogenic bacteria such as Shigella and Salmonella. Pathogenic behavior of Y. enterocolitica is discussed in comparison with that of Shigella and Salmonella.
利用从不同来源分离出的菌株经十二指肠接种成功在兔身上建立的实验模型，对小肠结肠炎耶尔森菌的致病性进行了分析。致病菌株很容易穿透肠黏膜的上皮衬里，进入肠道的目标网状内皮组织，如固有层和淋巴滤泡，在那里它们在单核细胞内繁殖并形成肉芽肿。在严重感染时，肉芽肿会发生渐进性坏死，有时会发展为溃疡，并伴有细菌菌落形成。在轻度感染时，肉芽肿性病变局限于淋巴滤泡，从不发展为溃疡。非致病菌株迅速排出，未穿透上皮衬里。小肠结肠炎耶尔森菌应属于侵袭型肠道病原菌，如志贺菌和沙门菌。将小肠结肠炎耶尔森菌的致病行为与志贺菌和沙门菌的致病行为进行了比较讨论。
