McCarthy D M, Coleman M
Lancet. 1979 Oct 27;2(8148):877-8. doi: 10.1016/s0140-6736(79)92688-6.
Eight autistic patients with steatorrhoea, hypocalciuria, and alleged behavioural improvements on gluten restriction, were fed ordinary diets plus 20 g gluten/day for 4 weeks. None of the patients had any significant change in body-weight or bowel habit as a result of gluten challenge, nor were any histological abnormalities detected on jejunal biopsy. The data suggest that the steatorrhoea and hypocalciuria seen in some autistic subjects cannot be accounted for by the presence of coeliac disease. Furthermore, these patients should not be confined to gluten-free diets, unless rigorous behavioural studies demonstrate a statistically significant improvement in behaviour as a result of the diet, or deterioration during challenge.
八名患有脂肪泻、低钙尿症且据称在限制麸质摄入后行为有所改善的自闭症患者，食用普通饮食并每天额外添加20克麸质，持续4周。麸质激发试验后，没有患者的体重或排便习惯出现任何显著变化，空肠活检也未检测到任何组织学异常。数据表明，一些自闭症患者出现的脂肪泻和低钙尿症不能用乳糜泻来解释。此外，除非严格的行为研究表明饮食导致行为有统计学上的显著改善，或者在激发试验期间行为恶化，否则这些患者不应局限于无麸质饮食。
