Nielsen K
Histopathology. 1984 Sep;8(5):759-64. doi: 10.1111/j.1365-2559.1984.tb02392.x.
Biopsies of the jejunum from 10 patients suffering from coeliac disease were investigated by an immunohistochemical technique for alpha-I-antitrypsin. The biopsies obtained before treatment did not contain alpha-I-antitrypsin, but after a gluten-free diet alpha-I-antitrypsin was present in Paneth cells in the mucosal crypts. This finding suggests that the absence of alpha-I-antitrypsin in the jejunal mucosa might be a pathogenetic factor in coeliac disease.
采用免疫组织化学技术对10例乳糜泻患者的空肠活检组织进行α1抗胰蛋白酶检测。治疗前获取的活检组织中未发现α1抗胰蛋白酶，但在无麸质饮食后，黏膜隐窝的潘氏细胞中出现了α1抗胰蛋白酶。这一发现表明空肠黏膜中α1抗胰蛋白酶的缺失可能是乳糜泻的一个致病因素。
