Bienvenu J, Doche C, Later R, Manceaux J C, Pontet F, Pressac M, Vassault A, Dumont G
Laboratoire d'immunologie, Centre hospitalier Lyon-Sud, Pierre-Bénite.
Ann Biol Clin (Paris). 1997 Jan-Feb;55(1):37-40.
The introduction of the CRM 470 in 1993 (certified reference material for 14 serum proteins) and its utilization by industrial companies for cross-calibrating their commercial standards has been an important break-through in protein standardization. This improvement has been clearly illustrated by the last national quality control survey performed in France in may 1995. At this time, about 60% of the 1,870 participants have already adopted the new standardization. The between-run precision (interlaboratory and intertechnique) has been considerably improved by the use of the new international standard (5.8 to 12.2% versus 10 to 24.1% before standardization); the same is true for accuracy. These results should convince the last reluctant laboratories to adopt the new standardization. Thus, it seems now possible to define reference ranges for serum proteins: this is the new task assigned to the Committee for Plasma Protein Standardization of the IFCC.
1993年CRM 470（14种血清蛋白的认证参考物质）的推出以及工业公司利用其对商业标准进行交叉校准，是蛋白质标准化方面的一项重要突破。1995年5月在法国进行的上一次全国质量控制调查清楚地说明了这一改进。当时，1870名参与者中约60%已经采用了新的标准化方法。使用新的国际标准后，批间精密度（实验室间和技术间）有了显著提高（标准化前为10%至24.1%，现在为5.8%至12.2%）；准确性方面也是如此。这些结果应该能说服最后几家仍持犹豫态度的实验室采用新的标准化方法。因此，现在似乎有可能确定血清蛋白的参考范围：这是国际临床化学与检验医学联合会血浆蛋白标准化委员会分配的新任务。
