Mewes Andrea U J, Zöllei Lilla, Hüppi Petra S, Als Heidelise, McAnulty Gloria B, Inder Terrie E, Wells William M, Warfield Simon K
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Neuroimage. 2007 Jul 15;36(4):1074-85. doi: 10.1016/j.neuroimage.2007.04.011. Epub 2007 Apr 18.
Regional investigations of newborn MRI are important to understand the appearance and consequences of early brain injury. Previously, regionalization in neonates has been achieved with a Talairach parcellation, using internal landmarks of the brain. Non-synostotic dolichocephaly defines a bi-temporal narrowing of the preterm infant's head caused by pressure on the immature skull. The impact of dolichocephaly on brain shape and regional brain shift, which may compromise the validity of the parcellation scheme, has not yet been investigated. Twenty-four preterm and 20 fullterm infants were scanned at term equivalent. Skull shapes were investigated by cephalometric measurements and population registration. Brain tissue volumes were calculated to rule out brain injury underlying skull shape differences. The position of Talairach landmarks was evaluated. Cortical structures were segmented to determine a positional shift between both groups. The preterm group displayed dolichocephalic head shapes and had similar brain volumes compared to the mesocephalic fullterm group. In preterm infants, Talairach landmarks were consistently positioned relative to each other and to the skull base, but were displaced with regard to the calvarium. The frontal and superior region was enlarged; central and temporal gyri and sulci were shifted comparing preterm and fullterm infants. We found that, in healthy preterm infants, dolichocephaly led to a shift of cortical structures, but did not influence deep brain structures. We concluded that the validity of a Talairach parcellation scheme is compromised and may lead to a miscalculation of regional brain volumes and inconsistent parcel contents when comparing infant populations with divergent head shapes.
对新生儿进行磁共振成像（MRI）的区域研究对于理解早期脑损伤的表现及后果至关重要。此前，新生儿的脑区划分是通过Talairach脑图谱法实现的，该方法利用脑内部的标志性结构。非骨性融合的长头畸形指的是早产儿头部因未成熟颅骨受到压力而导致的双侧颞部变窄。长头畸形对脑形状和脑区移位的影响尚未得到研究，而这种影响可能会损害脑图谱方案的有效性。对24名早产儿和20名足月儿在足月相当龄时进行了扫描。通过头影测量和群体配准来研究颅骨形状。计算脑组织体积以排除颅骨形状差异背后的脑损伤因素。评估Talairach标志性结构的位置。对皮质结构进行分割以确定两组之间的位置偏移。与中头型的足月儿组相比，早产儿组呈现长头型头部形状且脑体积相似。在早产儿中，Talairach标志性结构彼此之间以及相对于颅底的位置是一致的，但相对于颅骨则发生了移位。额叶和上部区域增大；与足月儿相比，中央回和颞回及脑沟发生了移位。我们发现，在健康的早产儿中，长头畸形导致了皮质结构的移位，但并未影响深部脑结构。我们得出结论，当比较头型不同的婴儿群体时，Talairach脑图谱方案的有效性受到损害，可能会导致脑区体积计算错误以及脑图谱内容不一致。
