Trémeau F, Clark S C, Printz D, Kegeles L S, Malaspina D
Department of Clinical Psychobiology, New York State Psychiatric Institute, New York 10032, USA.
Clin Neuropharmacol. 1997 Apr;20(2):168-70. doi: 10.1097/00002826-199704000-00009.
Clozapine often causes low-grade fever and less frequently spiking fever. We describe three cases of spiking fever that occurred in the first 3 weeks of clozapine therapy. A new set of side effects of clozapine is identified, which includes spiking fever, respiratory and gastrointestinal symptoms, and neutrophilia. Possible mechanisms are discussed.