Edwards M S
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Clin Perinatol. 1997 Mar;24(1):251-66.
This article reviews the effects of the physiologic changes accompanying pregnancy on the pharmacokinetics of antimicrobials commonly employed during pregnancy. The possible adverse effects on the fetus from maternal use of antibacterials and their excretion into breast milk are reviewed. Principles of antibiotic pharmacology in newborn infants are summarized. The indications for use, dosages, and potential for adverse effects are reviewed for antibiotics currently in use and for several agents for which approval is pending for use in the newborn.
本文综述了孕期伴随的生理变化对孕期常用抗菌药物药代动力学的影响。还综述了母亲使用抗菌药物对胎儿可能产生的不良反应及其向母乳中的排泄情况。总结了新生儿抗生素药理学原理。对目前正在使用的抗生素以及几种待批准用于新生儿的药物的使用指征、剂量和潜在不良反应进行了综述。
