Goldstein L B
Durham Veterans affairs Medical Center, NC 27710, USA.
Curr Opin Neurol. 1997 Feb;10(1):52-7. doi: 10.1097/00019052-199702000-00011.
Laboratory studies show that recovery after brain injury can be influenced by drugs that affect certain central neurotransmitters. The effects of these drugs may be either beneficial or harmful. Although issues related to drug dose, the timing of interventions relative to the deficit, and the nature of concomitant experience or training may be critical, preliminary clinical studies suggest that similar drug effects may occur in humans recovering from stroke. Recognition of these data is important because many of the drugs that may impair recovery are commonly prescribed to stroke patients for the treatment of coincident medical conditions and should be avoided if possible. Pharmacotherapy to enhance recovery may be possible in the future.
实验室研究表明，脑损伤后的恢复可能会受到影响某些中枢神经递质的药物的影响。这些药物的作用可能是有益的，也可能是有害的。尽管与药物剂量、相对于缺陷的干预时机以及伴随经验或训练的性质相关的问题可能至关重要，但初步临床研究表明，从中风中恢复的人类可能会出现类似的药物作用。认识到这些数据很重要，因为许多可能损害恢复的药物通常被开给中风患者用于治疗并发疾病，如果可能应避免使用。未来有可能通过药物治疗来促进恢复。
