Van Dyke C, Barash P G, Jatlow P, Byck R
Science. 1976 Feb 27;191(4229):859-61. doi: 10.1126/science.56036.
Cocaine (1.5 milligrams per kilogram) was applied to the nasal mucosa of human subjects. The cocaine persisted in the plasma for 4 to 6 hours and reached peak concentrations of 120 to 474 nanograms per milliliter at 15 to 60 minutes. In that residual cocaine was detectable on the nasal mucosa for 3 hours, continuous absorption secondary to its vasoconstrictive action might explain its persistence in the plasma.
将可卡因（每千克1.5毫克）应用于人体受试者的鼻黏膜。可卡因在血浆中持续存在4至6小时，在15至60分钟时达到每毫升120至474纳克的峰值浓度。由于在鼻黏膜上可检测到残留可卡因达3小时，其血管收缩作用继发的持续吸收可能解释了它在血浆中的持续存在。
