Burrows P D, Cooper M D
Department of Medicine, Pediatrics and Microbiology, University of Alabama at Birmingham 35294, USA.
Curr Opin Immunol. 1997 Apr;9(2):239-44. doi: 10.1016/s0952-7915(97)80142-2.
The initial phases of B cell development depend on interactions between the cell surface molecules and secreted products of stromal cells with their receptor-ligand partners on lymphoid progenitors. Recent research in this area has greatly advanced our understanding of B cell development and differentiation. Antigen receptors on pre-B and B cells play key roles in the progression of this differentiation process, as revealed by targeted and inherited gene mutations that disrupt B cell development and by the transgenic repair of these mutations in mice.
B细胞发育的初始阶段取决于基质细胞的细胞表面分子和分泌产物与其在淋巴祖细胞上的受体-配体伙伴之间的相互作用。该领域的最新研究极大地推进了我们对B细胞发育和分化的理解。前B细胞和B细胞上的抗原受体在这一分化过程的进展中发挥关键作用，这一点已通过破坏B细胞发育的靶向和遗传性基因突变以及小鼠中这些突变的转基因修复得以揭示。
