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[古热罗-舍格伦综合征中的肌肉病变]

[Muscular lesions in Gougerot-Sjögren syndrome].

作者信息

Serratrice G, Pellissier J F, Roux H, Gastaut J L, Acquaviva P

出版信息

Rev Rhum Mal Osteoartic. 1977 Jul-Sep;44(7-9):479-88.

PMID:910106
Abstract

The authors review the literautre and then proceed to analyse a series of 16 cases of Gougerot Sjögren Syndrome. The electromyogram (EMG) was abnormal on only 2 occasions. Histologically inflammatory aspects could be seen on 4 occasions with perifascicular atrophy in one case. Atrophy of II fibres was present in 7 cases together with signs of disorganization of the mitochondrial reticulum and images of mitochondrial aggregates. Under the electron microscope minor anomalies were particularly visiole and the internal structure was normal as often as not. Overall it is possible to distinguish forms of a subacute polymyositis type (4 cases), and a pauci-inflammatory myalgic type proximal to the scappular predominance (4 cases), in which the mitochondrial anomalies are commonest. Another "infraclinical" group shows no other frankly pathological changes. Finally in 3 cases the "dry" syndrome is strictly free of any muscular attack.

摘要

作者回顾了文献,然后着手分析16例古热罗-舍格伦综合征病例。肌电图(EMG)仅在2例中异常。组织学上,4例可见炎症表现,其中1例伴有束周萎缩。7例存在Ⅱ型纤维萎缩,同时有线粒体网状结构紊乱的迹象和线粒体聚集图像。在电子显微镜下,轻微异常尤为明显,而内部结构通常正常。总体而言,可以区分出亚急性多发性肌炎型(4例)和肩胛带近端少炎性肌痛型(4例),其中线粒体异常最为常见。另一个“亚临床”组未显示出其他明显的病理变化。最后,在3例中,“干燥”综合征完全没有任何肌肉受累情况。

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