Martínez-Lavín M, Hermosillo A G, Mendoza C, Ortiz R, Cajigas J C, Pineda C, Nava A, Vallejo M
Instituto Nacional de Cardiolagía Ignacio Chávez, Hospital Gea Gonzalez, México DF, México.
J Rheumatol. 1997 Apr;24(4):714-8.
To assess the sympathetic-parasympathetic balance in individuals with fibromyalgia (FM), and its response to orthostatic stress, by power spectral analysis of heart rate variability.
We studied 19 women with FM and 19 age matched controls. A high resolution electrocardiogram was obtained in supine and standing postures after achieving a stable heart rate. Spectral analysis of R-R intervals was done by the fast Fourier transform algorithm.
Analyses of the different frequency components revealed significant difference between the 2 groups in the low frequency (0.050-0.150 Hz) band, which reflects modulation of the sympathetic nervous system. Controls displayed an increased power spectral density upon standing (+0.081 +/- 0.217 Hz); individuals with FM had a discordant response (-0.057 +/- 0.097 Hz) (p = 0.018).
In FM, there is a deranged sympathetic response to orthostatic stress. This abnormality may have implications regarding the pathogenesis of FM.
通过心率变异性的功率谱分析，评估纤维肌痛（FM）患者的交感 - 副交感神经平衡及其对直立位应激的反应。
我们研究了19名患有FM的女性和19名年龄匹配的对照组。在心率稳定后，以仰卧位和站立位获取高分辨率心电图。通过快速傅里叶变换算法对R-R间期进行频谱分析。
对不同频率成分的分析显示，两组在反映交感神经系统调制的低频（0.050 - 0.150 Hz）频段存在显著差异。对照组站立时功率谱密度增加（+0.081 +/- 0.217 Hz）；FM患者有不一致的反应（-0.057 +/- 0.097 Hz）（p = 0.018）。
在FM中，对直立位应激存在交感反应紊乱。这种异常可能与FM的发病机制有关。
