Cohen H, Neumann L, Alhosshle A, Kotler M, Abu-Shakra M, Buskila D
Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
J Rheumatol. 2001 Mar;28(3):581-9.
It is possible that there are differences in clinical manifestations between men and women with fibromyalgia syndrome (FM), especially in autonomic dysfunction; we assessed the interaction between the sympathetic and parasympathetic systems in postural change in men with FM using power spectral analysis (PSA) of heart rate variability (HRV), and investigated the pathogenesis of the orthostatic intolerance.
We studied 19 men with FM and 19 controls matched for age and sex. A high resolution electrocardiogram was obtained in supine and standing postures during complete rest. Spectral analysis of R-R intervals was done by the fast Fourier transform algorithm.
PSA of HRV revealed that men with FM at rest are characterized by sympathetic hyperactivity and concomitantly reduced parasympathetic activity. During postural changes, male patients demonstrated an abnormal sympathovagal response. These results provide the physiological basis for the orthostatic intolerance in men with FM.
This report of autonomic dysfunction in men with FM revealed an abnormal autonomic response to orthostatic stress. This abnormality may have implications regarding the symptoms of FM.
纤维肌痛综合征（FM）患者中男性和女性的临床表现可能存在差异，尤其是在自主神经功能障碍方面；我们使用心率变异性（HRV）的功率谱分析（PSA）评估了FM男性患者体位改变时交感神经系统与副交感神经系统之间的相互作用，并研究了直立不耐受的发病机制。
我们研究了19名患有FM的男性以及19名年龄和性别相匹配的对照者。在完全休息状态下，分别于仰卧位和站立位记录高分辨率心电图。采用快速傅里叶变换算法对R-R间期进行频谱分析。
HRV的PSA显示，静息状态下的FM男性患者具有交感神经活动亢进且副交感神经活动同时降低的特征。在体位改变过程中，男性患者表现出异常的交感迷走反应。这些结果为FM男性患者的直立不耐受提供了生理基础。
本报告关于FM男性患者自主神经功能障碍的研究揭示了其对直立应激的异常自主神经反应。这种异常可能与FM的症状有关。
