Mallette L E
South Med J. 1977 Oct;70(10):1199-201. doi: 10.1097/00007611-197710000-00014.
A series of patients with primary hyperparathyroidism showed a high incidence of anemia. Red cell morphology and indices, iron, folate and B12 were generally normal and reticulocyte counts inappropriately low. Focal fibrosis of the marrow space was observed in marrow biopsies from two patients, but no patient showed overt signs of a myelophthisic process. Anemia tended to occur in those with more severe hyperparathyroidism (higher serum calcium level or radiographic osteitis fibrosa cystica). Since severe hyperparathyroidism frequently compromises renal function, it is not always clear whether the anemia should be attributed to renal failure or to the metabolic disease. In nine of the 24 anemic patients, however, renal function was normal. Hyperparathyroidism may cause a hyporegenerative anemia, the mechanisms for which have not been elucidated.
一系列原发性甲状旁腺功能亢进患者显示出贫血的高发生率。红细胞形态和指数、铁、叶酸和维生素B12通常正常，网织红细胞计数异常低。在两名患者的骨髓活检中观察到骨髓腔局灶性纤维化，但没有患者表现出明显的骨髓病性过程迹象。贫血倾向于发生在甲状旁腺功能亢进更严重（血清钙水平更高或影像学上有纤维囊性骨炎）的患者中。由于严重的甲状旁腺功能亢进经常损害肾功能，因此贫血应归因于肾衰竭还是代谢性疾病并不总是很清楚。然而，在24名贫血患者中有9名肾功能正常。甲状旁腺功能亢进可能导致再生低下性贫血，其机制尚未阐明。
