Lemperle G, al Soufi A
Frankfurter Klinik für Plastische und Wiederherstellungschirurgie.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:1128-34.
In general, all biological materials are resorbed in places where they do not belong. Therefore, artificial substances have to be implanted under deep skin folds and skin defects in order to achieve a permanent skin augmentation. Artecoll, a suspension of polymethylmetcrylate (PMMA)-microspheres in collagen solution, has been proven, for more than 5 years, to underlay wrinkles effectively without noticeable side-effects. Small wrinkles around the eyes, the mouth and cheeks, however, have to be treated by dermabrasion, chemical peel or vaporization by CO2-laser. Using all three methods, the effectiveness depends on the depth of skin traumatisation. Resurfacing using the CO2-laser has the advantage of absolute precision, no bleeding, less swelling and faster healing-but still high costs.
一般来说，所有生物材料都会在其不该存在的部位被吸收。因此，必须将人工物质植入深皮肤褶皱和皮肤缺损处，以实现永久性的皮肤增厚。爱贝芙（Artecoll），一种聚甲基丙烯酸甲酯（PMMA）微球悬浮于胶原蛋白溶液中的产品，在超过5年的时间里已被证实能有效填平皱纹且无明显副作用。然而，眼周、口周和脸颊周围的小皱纹必须通过磨皮术、化学换肤术或二氧化碳激光汽化术来治疗。使用这三种方法，其效果取决于皮肤创伤的深度。使用二氧化碳激光进行皮肤表面重建具有绝对精确、不出血、肿胀较轻且愈合较快的优点——但成本仍然很高。
