Rogaev E I, Ovchinnikov I V, Dzhorzh-Khislop P, Rogaeva E A
University of Toronto, Canada.
Genetika. 1996 Dec;32(12):1690-2.
Analysis of two polymorphic regions of mitochondrial DNA obtained from T. N. Kulikovskii-Romanov, the nephew of the last Tsar of the Russian Empire Nikolai II Romanov, was performed. The mitochondrial DNA sequences of T. N. Kulikovskii-Romanov and earlier reported DNA sequences obtained from the putative remains of Nikolai II showed almost complete coincidence except for a single nucleotide at the position 16169. At this position, C was found in mitochondrial DNA of T. N. Kulikovskii-Romanov, C/T in that from the putative remains of Nikolai II Romanov, and T in mitochondrial DNA from great great grandson and great great grand-daughter of Louise Hesse-Cassel. These data suggest independent mutations in the maternal lineage of Louise Hesse-Cassel's descendants and/or a mutation leading to a heteroplasmia in the lineage of Louise Hesse-Cassel.
对从俄罗斯帝国末代沙皇尼古拉二世·罗曼诺夫的侄子T. N. 库利科夫斯基-罗曼诺夫处获得的线粒体DNA的两个多态性区域进行了分析。T. N. 库利科夫斯基-罗曼诺夫的线粒体DNA序列与先前报道的从尼古拉二世假定遗体中获得的DNA序列几乎完全一致，除了位置16169处的一个单核苷酸。在这个位置，T. N. 库利科夫斯基-罗曼诺夫的线粒体DNA中发现的是C，从尼古拉二世假定遗体中获得的线粒体DNA中是C/T，而路易丝·黑森-卡塞尔的玄孙和玄孙女的线粒体DNA中是T。这些数据表明路易丝·黑森-卡塞尔后代的母系谱系中存在独立突变和/或路易丝·黑森-卡塞尔谱系中导致异质性的突变。
