Verkerk R, van der Gaag M S, Dekker M, Jongen W M
Department of Food Science, Wageningen Agricultural University, The Netherlands.
Cancer Lett. 1997 Mar 19;114(1-2):193-4. doi: 10.1016/s0304-3835(97)04661-2.
Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological active compounds. Some compounds, for example isothiocyanates, show an anticarcinogenic action by inducing phase II biotransformation enzyme activity (Jongen, Proc. Nutr. Soc. 1996; 55: 433-446). Processing of brassica vegetables influences glucosinolate degradation and therefore the biological activity. We investigate the effects of processing conditions on glucosinolates and their breakdown products. Besides measurement of concentrations also the biological activity of these compounds will be analysed.
硫代葡萄糖苷是十字花科植物中一类明确的次生植物代谢产物。它们尤其存在于芸苔属蔬菜中，而芸苔属蔬菜是人类饮食的主要组成部分。硫代葡萄糖苷在内源植物酶——黑芥子酶的催化下发生水解，生成一系列生物活性化合物。一些化合物，例如异硫氰酸酯，通过诱导II相生物转化酶活性表现出抗癌作用（容根，《营养学会会刊》1996年；55: 433 - 446）。芸苔属蔬菜的加工会影响硫代葡萄糖苷的降解，进而影响其生物活性。我们研究加工条件对硫代葡萄糖苷及其分解产物的影响。除了测量浓度外，还将分析这些化合物的生物活性。
