Satoh I, Hogan J F, Glenn W W, Fujii Y
Trans Am Soc Artif Intern Organs. 1977;23:456-63. doi: 10.1097/00002480-197700230-00122.
A PACO2 feedback control system (demand diaphragm pacemaker) was developed in this laboratory to maintain homeostasis during diaphragm pacing, thus avoiding hypo- or hyperventilation. Application of this system to the research animal made it possible to maintain blood gases and pH within normal limits for up to 15 hrs. Oscillation between maximal tidal volume and apnea that occurred with the amplitude feedback control was eliminated by using a rate feedback control. A possible additional benefit of a feedback control system is the reduction of current applied to the nerve as compared to that in asynchronous pacing, thereby minimizing the fatigue phenomenon.
本实验室开发了一种PACO2反馈控制系统（按需膈肌起搏器），以在膈肌起搏期间维持体内平衡，从而避免通气不足或过度通气。将该系统应用于实验动物，可使血气和pH值在正常范围内维持长达15小时。通过使用速率反馈控制，消除了幅度反馈控制时出现的最大潮气量与呼吸暂停之间的振荡。与非同步起搏相比，反馈控制系统的一个可能的额外好处是减少了施加到神经的电流，从而使疲劳现象最小化。
