Kimura M, Sugiura T, Fukui Y, Kimura T, Harada Y
Graduate School of Electronic Science & Technology, Shizuoka University, Hamamatsu, Japan.
Med Biol Eng Comput. 1992 Mar;30(2):155-61. doi: 10.1007/BF02446125.
Two ways of rate control for diaphragm pacing are proposed. One is rate control using only the patients' body temperature (method I). The other is rate control by both the patients' heart rate and body temperature (method II). To test the effectiveness of these methods, a diaphragm pacemaker which can be controlled by both heart rate and body temperature has been developed. It was applied to nine mongrel dogs. The pacing rate is controlled by atrial blood temperature (method I) or by both heart rate and temperature (method II). The animal's metabolism was elevated by the administration of a pyrogenic drug. It was found that method I is not suited to rapid changes in metabolism; however, it is useful in extreme metabolic elevation. An animal's metabolism was supported by using method II in all ranges of metabolism. This method proved more effective than method I for rate-responsive diaphragm pacing.
提出了两种用于膈肌起搏的速率控制方法。一种是仅使用患者体温进行速率控制（方法I）。另一种是通过患者心率和体温两者进行速率控制（方法II）。为了测试这些方法的有效性，已经开发出一种可通过心率和体温进行控制的膈肌起搏器。它被应用于9只杂种犬。起搏速率通过心房血温进行控制（方法I）或通过心率和体温两者进行控制（方法II）。通过给予致热药物来提高动物的新陈代谢。结果发现，方法I不适合新陈代谢的快速变化；然而，它在极端代谢升高时是有用的。在所有新陈代谢范围内，使用方法II来维持动物的新陈代谢。事实证明，这种方法在速率响应性膈肌起搏方面比方法I更有效。
