Kazak A E, Barakat L P, Meeske K, Christakis D, Meadows A T, Casey R, Penati B, Stuber M L
Division of Oncology, Children's Hospital of Philadelphia, Pennsylvania 19104-4399, USA.
J Consult Clin Psychol. 1997 Feb;65(1):120-9. doi: 10.1037//0022-006x.65.1.120.
Psychological sequelae are examined in 130 former childhood leukemia patients and 155 comparison participants and their parents. The major dependent variables are symptoms of anxiety and posttraumatic stress, family functioning, and social support. Multivariate analyses of covariance indicated significantly more posttraumatic stress symptoms in mothers and fathers of childhood leukemia survivors (p < .001) and no differences between survivors and peers. There were no significant group differences for family functioning or social support, although they were associated with anxiety and posttraumatic stress outcomes. Current child age, age at diagnosis, and months off treatment were not significantly correlated with outcome. These findings document the long-term impact of childhood cancer treatment on parents. The lack of significant differences for survivors argues for further attention to the relevance of posttraumatic stress disorder for childhood cancer survivors. The clinical implications are that psychological interventions are needed during and after cancer treatment.
对130名曾患儿童白血病的患者、155名对照参与者及其父母进行了心理后遗症检查。主要因变量为焦虑症状、创伤后应激症状、家庭功能和社会支持。多变量协方差分析表明，儿童白血病幸存者的父母中创伤后应激症状明显更多（p <.001），幸存者与同龄人之间没有差异。家庭功能或社会支持方面没有显著的组间差异，尽管它们与焦虑和创伤后应激结果相关。目前儿童的年龄、诊断时的年龄以及停止治疗的月数与结果没有显著相关性。这些发现证明了儿童癌症治疗对父母的长期影响。幸存者之间缺乏显著差异，这表明需要进一步关注创伤后应激障碍与儿童癌症幸存者的相关性。临床意义在于，在癌症治疗期间和之后都需要进行心理干预。
