Mori S
Department of Neurology, Niigata Saiseikai Second General Hospital.
Nihon Rinsho. 1997 Apr;55(4):987-92.
Kuru, the progressive and fatal neurologic disorder which occurred exclusively among natives of the New Guinea Highlands, were reviewed. Early history of kuru investigation, epidemiology, clinical findings, pathological findings, successful transmission with chimpanzees, from unconventional virus to prion hypothesis and the similarities to "variant of Creutzfeldt-Jakob disease" were discussed in the literature. Although the incidence of kuru has markedly declined with the suppression of cannibalism, it is important from a historical perspective because it was the first human transmissible prion disease to be recognized.
对库鲁病（一种仅发生在新几内亚高地原住民中的进行性致命性神经疾病）进行了综述。文献中讨论了库鲁病研究的早期历史、流行病学、临床发现、病理发现、在黑猩猩身上的成功传播、从非常规病毒到朊病毒假说以及与“克雅氏病变异型”的相似之处。尽管随着食人行为的抑制，库鲁病的发病率已显著下降，但从历史角度来看它很重要，因为它是第一种被确认的人类可传播朊病毒疾病。
