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分枝杆菌索状因子的肉芽肿形成活性和霉菌酸组成

Granuloma formation activity and mycolic acid composition of mycobacterial cord factor.

作者信息

Baba T, Natsuhara Y, Kaneda K, Yano I

机构信息

Department of Bacteriology, Osaka City University Medical School, Japan.

出版信息

Cell Mol Life Sci. 1997 Mar;53(3):227-32. doi: 10.1007/pl00000595.

DOI:10.1007/pl00000595
PMID:9104485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11147429/
Abstract

We analyzed the mycolic acid composition of trehalose 6,6'-dimycolate (TDM) obtained from Mycobacterium, using thin layer chromatography, gas chromatography and gas chromatography-mass spectrometry. Utilizing TDM, whose structure was confirmed, granuloma formation in mice was investigated. All TDM used exhibited considerable granuloma formation activity in the lung and spleen. In particular, TDM from M. bovis showed the greatest activity and toxicity among mycobacterial TDM. We therefore discussed the relationship between the chemical structure and granuloma-forming activity of TDM, especially in relation to the structure of mycolic acid in TDM.

摘要

我们采用薄层色谱法、气相色谱法和气相色谱 - 质谱联用法，分析了从分枝杆菌中获得的海藻糖6,6'-二霉菌酸酯（TDM）的霉菌酸组成。利用结构已确认的TDM，研究了小鼠体内肉芽肿的形成情况。所有使用的TDM在肺和脾脏中均表现出相当程度的肉芽肿形成活性。特别是，来自牛分枝杆菌的TDM在分枝杆菌TDM中表现出最大的活性和毒性。因此，我们讨论了TDM的化学结构与肉芽肿形成活性之间的关系，尤其是与TDM中霉菌酸结构的关系。