Wall T L, Garcia-Andrade C, Thomasson H R, Carr L G, Ehlers C L
Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA.
Alcohol Alcohol. 1997 Mar-Apr;32(2):129-32. doi: 10.1093/oxfordjournals.alcalc.a008246.
Alcohol dehydrogenase (ADH) polymorphisms were evaluated among 95 Native American Mission Indians. Approximately equal frequencies of ADH31 and ADH32 alleles were found. Twelve individuals were heterozygous for ADH23, an allele previously identified only in persons of African origin. None of the individuals with ADH23 alleles was of purely Native American descent, although none had known African ancestry. These results suggest that these candidate genes deserve broader study among Native Americans and may provide increased understanding of the likely polygenic contributions to alcohol-related disorders in this population.
在95名美洲原住民米申印第安人中评估了酒精脱氢酶（ADH）多态性。发现ADH31和ADH32等位基因的频率大致相等。12人是ADH23的杂合子，该等位基因先前仅在非洲裔人群中发现。虽然没有已知非洲血统，但所有携带ADH23等位基因的个体都不是纯美洲原住民后裔。这些结果表明，这些候选基因值得在美洲原住民中进行更广泛的研究，并且可能有助于更好地理解该人群中酒精相关疾病可能的多基因贡献。
