Zaldívar R
Zentralbl Bakteriol Orig B. 1977 Aug;164(5-6):481-4.
The city of Antofagasta (northern Chile), is an area of endemic chronic arsenic poisoning due to arsenic-polluted drinking water. In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups. The sample (N = 220) included 13 males and 13 females in each age group, except the 81-90 year-old group with 6 males and 6 females. A linear relationship was found between arsenic dose (mg/kg body weight/day) and age for males being P less than 0.001 (slope) and r = -0.6712; and for females P less than 0.001 (slope) and r = 0.6667. Age-specific prevalence rates per 100,000 population (both sexes combined) for chronic arsenic poisoning in Antofagasta Commune for the 1968-71 period, were plotted against mean arsenic doses (mg/kg body weight/day) by age group. A dose-response curve was computed, being F = 83.19, d.f. = 1,7 and P less than 0.01 (slope). The correlation coefficient was + 0.9604.
安托法加斯塔市（智利北部）是一个因饮用水受砷污染而存在地方性慢性砷中毒的地区。为了探究剂量反应关系的可能性，1972年在该市开展了一项饮食调查，以测量不同年龄组的每日液体摄入量。样本（N = 220）中，除81 - 90岁年龄组有6名男性和6名女性外，每个年龄组均有13名男性和13名女性。男性的砷剂量（毫克/千克体重/天）与年龄之间存在线性关系，P小于0.001（斜率），r = -0.6712；女性的P小于0.001（斜率），r = 0.6667。将1968 - 1971年期间安托法加斯塔公社每10万人口（男女合计）的特定年龄慢性砷中毒患病率，按年龄组与平均砷剂量（毫克/千克体重/天）绘制图表。计算出一条剂量反应曲线，F = 83.19，自由度 = 1,7，P小于0.01（斜率）。相关系数为 + 0.9604。
