Zaldívar R, Villar I, Wetterstrand W H, Robinson H
Zentralbl Bakteriol B. 1978 Sep;167(3):242-7.
An epidemiological, dietary, toxicological and clinical nutrition study, in an area with endemic chronic arsenic poisoning, was made. In a pilot study on 100 subjects from Antofagasta Commune, water dietary intake was associated with age (r = 0.678; P less than 0.000005). In a dietary survey (N = 220), performed to measure the mean and median arsenic doses, by age groups, there was a significant correlation amongst males (r = 0.800; P = 0.00956) and females (r = -0.791; P = 0.01121). A nutritional assessment of a male population sample (N = 100), of labourers and their children, showed a negative per cent change for food energy in 9 of the 10 age groups, with a maximum negative value of -47.4 (11--12 year-old group), when compared with U.S. recommended daily dietary allowances. For total protein intake, all age groups exhibited a negative per cent change, reaching a maximum value of -27.8 (7--10 year-old group). Since two boys with chronic arsenical dermatosis and prekwashiorkor were drinking water with a mean arsenic concentration of 0.08 and 0.06 ppm, respectively, a maximum permissible concentration of arsenic in drinking water of 0.01 ppm has been recommended as an international safety standard.
在一个地方性慢性砷中毒地区开展了一项流行病学、饮食、毒理学及临床营养研究。在一项针对安托法加斯塔公社100名受试者的初步研究中，水的饮食摄入量与年龄相关（r = 0.678；P < 0.000005）。在一项饮食调查（N = 220）中，为按年龄组测量砷剂量的均值和中位数，男性（r = 0.800；P = 0.00956）和女性（r = -0.791；P = 0.01121）之间存在显著相关性。对100名男性劳动者及其子女的样本进行营养评估发现，与美国推荐的每日膳食摄入量相比，10个年龄组中有9个组的食物能量百分比变化为负，最大值为-47.4（11 - 12岁组）。对于总蛋白质摄入量，所有年龄组的百分比变化均为负，最大值为-27.8（7 - 10岁组）。由于两名患有慢性砷性皮炎和恶性营养不良的男孩分别饮用平均砷浓度为0.08 ppm和0.06 ppm的水，因此建议将饮用水中砷的最大允许浓度定为0.01 ppm作为国际安全标准。
