Boutin P, Maziade M, Mérette C, Mondor M, Bédard C, Thivierge J
Centre de recherche Université Laval Robert-Giffard, Beauport (Québec), Canada.
J Autism Dev Disord. 1997 Apr;27(2):165-76. doi: 10.1023/a:1025891824269.
We compared with a family history method the rate of cognitive disabilities (CD) in 156 first-degree relatives of 49 autistic (AU) probands to that found in 55 first-degree relatives of 18 mentally retarded (MR) probands. Broadly defined CD were found in, respectively, 17 and 16% of the relatives of the AU and MR probands. However, the characteristics of the probands associated with a family history of CD are different in AU and MR: Female and low IQ AU probands have more first-degree relatives with CD. Our findings suggest that a positive family history of CD is not specific to autism when compared to mental retardation. The observation that female and low IQ probands have higher family history of CD may suggest heterogeneity within autistic children and provides leads for future family studies.
我们采用家族史方法，比较了49名自闭症（AU）先证者的156名一级亲属与18名智力迟钝（MR）先证者的55名一级亲属中认知障碍（CD）的发生率。在AU和MR先证者的亲属中，广义定义的CD分别在17%和16%中被发现。然而，与CD家族史相关的先证者特征在AU和MR中有所不同：女性和低智商的AU先证者有更多患有CD的一级亲属。我们的研究结果表明，与智力迟钝相比，CD的阳性家族史并非自闭症所特有。女性和低智商先证者有更高的CD家族史这一观察结果可能表明自闭症儿童存在异质性，并为未来的家族研究提供了线索。
