Johnson J P, Muhleman D, MacMurray J, Gade R, Verde R, Ask M, Kelley J, Comings D E
Jerry L. Pettis VA Hospital, Loma Linda, CA, USA.
Mol Psychiatry. 1997 Mar;2(2):169-71. doi: 10.1038/sj.mp.4000246.
In our prior study we observed a significant association between homozygosity for the > or = alleles of a microsatellite polymorphism of cannabinoid receptor genes (CNR1) and drug dependence. Decreased amplitude of the P300 wave of evoked related potentials (ERP) has long been shown to be associated with alcohol and drug dependence. The P300 wave reflects attentional resource allocation and active working memory. Since marijuana intoxication has a potent blocking effect on short-term memory we examined the association between the CNR1 alleles and the P300 wave amplitude at three electrodes in 35 alcohol and drug addicts, by MANOVA. There was a significant decrease in amplitude of the P300 wave for all three electrodes (P = 0.028) that was most marked for the frontal lobes (P = 0.008) in subjects homozygous for the CNR1 > or = 5 repeat alleles. Multivariate regression analysis indicated the CNR1 gene contributed to 20% of the variance of the frontal lobe P300 wave amplitude.
在我们之前的研究中，我们观察到大麻素受体基因（CNR1）微卫星多态性的>或=等位基因的纯合性与药物依赖之间存在显著关联。长期以来，诱发电位（ERP）的P300波幅降低一直被证明与酒精和药物依赖有关。P300波反映了注意力资源分配和主动工作记忆。由于大麻中毒对短期记忆有显著的阻断作用，我们通过多变量方差分析研究了35名酒精和药物成瘾者中CNR1等位基因与三个电极处P300波幅之间的关联。对于CNR1>或=5重复等位基因纯合的受试者，所有三个电极的P300波幅均显著降低（P = 0.028），其中额叶最为明显（P = 0.008）。多变量回归分析表明，CNR1基因对额叶P300波幅变异的贡献率为20%。
