Tolochko Z S, Knyazeva G B
Laboratory of Neuromorphology, Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk.
Brain Res. 1997 Mar 28;752(1-2):324-6. doi: 10.1016/s0006-8993(96)01323-6.
Contralateral increased exudation of plasma proteins, as measured by Evans Blue leakage into the fore paws, was produced by unilateral electrocoagulation of the mamillary nuclei in rats. Ten days after adult capsaicin pretreatment (increasing doses/4 days total 200 mg/kg, s.c.) the unilateral destruction of these nuclei did not evoke any changes of skin blood vessel permeability in both contralateral and unilateral paws. The findings show that the central nervous system may modulate the capsaicin-sensitive peptidergic neuron action on blood vessel permeability.
通过伊文思蓝渗漏到前爪来测量，大鼠乳头体核单侧电凝会导致对侧血浆蛋白渗出增加。成年大鼠预先给予辣椒素（剂量递增，共4天，200mg/kg，皮下注射）10天后，这些核团的单侧破坏并未引起对侧和同侧爪皮肤血管通透性的任何变化。研究结果表明，中枢神经系统可能会调节辣椒素敏感肽能神经元对血管通透性的作用。
